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"What are effective treatment options for individuals with 10 years of treatment resistant depression?"

Approximately 30% of people diagnosed with major depressive disorder experience treatment-resistant depression.

Treatment-resistant depression is not the same as untreatable depression; it simply means that at least two different antidepressants have been tried without sufficient improvement.

Exercise has been shown to reduce symptoms of depression by 43% in people with treatment-resistant depression.

Even small amounts of physical activity, such as 10-15 minutes of daily walking, can improve depression symptoms.

A 2019 study found that 60% of people with treatment-resistant depression had undiagnosed sleep disorders, which can exacerbate symptoms.

Transcranial magnetic stimulation (TMS) has been shown to be effective in 50-60% of people with treatment-resistant depression.

Ketamine, an anesthetic drug, has been found to provide rapid relief from treatment-resistant depression in low doses, with an average response rate of 55%.

Mindfulness-based cognitive therapy (MBCT) has been shown to reduce relapse rates by 43% in people with treatment-resistant depression.

A 2020 study found that 70% of people with treatment-resistant depression had a history of childhood trauma, which can impact treatment outcomes.

Treatment-resistant depression is more prevalent in bipolar depression than in major depressive disorder.

The likelihood of treatment-resistant depression increases with each subsequent treatment failure, with 50% of people experiencing treatment failure after two antidepressant trials.

A 2018 study found that 40% of people with treatment-resistant depression had undiagnosed attention deficit hyperactivity disorder (ADHD), which can impact treatment outcomes.

People with treatment-resistant depression are 10-15 times more likely to experience suicidal ideation compared to those without TRD.

A 2020 study found that people with treatment-resistant depression have altered gut microbiomes, which may contribute to treatment resistance.

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